Endocrine Abstracts

Cranial diabetes insipidus in critically ill patient increases the complexity of fluid management. Well patients with cranial diabetes insipidus can drink enough fluid to replace their urine losses driven by their thirst mechanisms. In critically ill patients the thirst response cannot be relied upon. When fluid input is not adequate it results in hypernatremia. Here dextrose, water or hypo-tonic intravenous fluid is used. Complications related to this are high glucose levels,...

Hyperthyroidism is not a well-known cause of venous thromboembolism. Hyper-coagulable and hypofibrinolytic states are described in hyperthyroidism. A meta-analysis of 51 studies evaluating the consequence (exogenous and endogenous effect on coagulation, raised thyroid levels were associated with a rise in clotting factor VIII, IX, Von Willebrand factor and fibrinogen. The procoagulant effect noticed in hyperthyroidism facilitated by thyroid hormone receptor beta gene. 40-year-...

Case History: We describe a case of a 30-year-old female who presented at 8 weeks postpartum with history of altered behaviour, clouding of consciousness and status epilepticus. She had been diagnosed with autoimmune graves thyroid disease and was commenced on carbimazole prior to this episode. She was treated as meningoencephalitis. Also, consideration was given for possibility of thyroid storm and post-partum eclampsia. She was intubated and ventilated, treated with IV acycl...

Introduction: Pulmonary neuroendocrine tumours (pulNETs) histologically encompass: small cell, large cell, typical (TC) and atypical carcinoid (AC). Diffuse idiopathic pulmonary neuroendocrine hyperplasia (DIPNECH) is a very rare condition but potentially progress to pulNET and is associated with MEN. Advances in treatment have modified management, and there have been recommendations to use Ki67 for grading. However there is a paucity of randomized studies.<p class="abstex...

Pancreatic neuroendocrine tumours are rare with an incidence of 5 per million. Of these tumours, 75% maybe hormonally functioning. They carry a better prognosis than adenocarcinoma of the pancreas. Parathyroid Hormone related peptide hypersecretion in PNETs is uncommon and is solely associated with metastatic PNETs. 31 cases are reported of PTH-rPoma in the literature. Here we describe a novel case presenting with cough. A previously well 56-year-old female presented to the ac...